Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...

¹H NMR: Long-Range Coupling

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene π orbitals.

Spin–Spin Coupling: One-Bond Coupling

Spin–Spin Coupling: One-Bond Coupling

Coupling interactions are strongest between NMR-active nuclei bonded to each other, where spin information can be transmitted directly through the pair of bonding electrons. While nuclei polarize their electrons to the opposite spins, the bonding electron pair has opposite spins. Configurations with antiparallel nuclear spins are expected to be lower in energy. When coupling makes antiparallel states more favorable, J is considered to have a positive value. The one-bond coupling constant, 1J,...

2D NMR: Overview of Heteronuclear Correlation Techniques

2D NMR: Overview of Heteronuclear Correlation Techniques

Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other axis.

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)

Heteronuclear single-quantum correlation spectroscopy (HSQC) is a 2D NMR technique that reveals one-bond correlations between hydrogen and a heteronucleus. The HSQC experiment is similar to the heteronuclear correlation experiment (HETCOR) but is more sensitive. In the HSQC spectrum, the proton chemical shift is plotted on the horizontal F2 axis, while the 13C chemical shift is plotted on the vertical F1 axis. The corresponding proton and 13C spectra are also shown. The HSQC contour plot does...

Spin–Spin Coupling Constant: Overview

Spin–Spin Coupling Constant: Overview

In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must have a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CaloChallenge 2022: a community challenge for fast calorimeter simulation.

Reports on progress in physics. Physical Society (Great Britain)·2025

Same author

Percentage of culture confirmation and melting curve analysis reveals false-positive <i>Campylobacter</i> detection in a molecular syndromic panel.

Journal of clinical microbiology·2025

Same author

Case report: Cerebral amyloid angiopathy-related inflammation in a patient with granulomatosis with polyangiitis.

Frontiers in neurology·2023

Same author

Highly Efficient Additive-Free Dehydrogenation of Neat Formic Acid.

Nature catalysis·2023

Same author

Dehydrogenative ester synthesis from enol ethers and water with a ruthenium complex catalyzing two reactions in synergy.

Green chemistry : an international journal and green chemistry resource : GC·2022

Same author

Efficient Base-Free Aqueous Reforming of Methanol Homogeneously Catalyzed by Ruthenium Exhibiting a Remarkable Acceleration by Added Catalytic Thiol.

Journal of the American Chemical Society·2021

Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026

Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026

Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026

Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026

Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026

Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 18, 2026

Setting Limits on Supersymmetry Using Simplified Models

Setting Limits on Supersymmetry Using Simplified Models

Published on: November 15, 2013

Measuring Higgs couplings from LHC data.

Markus Klute¹, Rémi Lafaye, Tilman Plehn

¹Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Physical Review Letters

|September 26, 2012

Summary

This summary is machine-generated.

Researchers analyzed Higgs boson data from ATLAS and CMS experiments, determining Higgs couplings and constraining modified Higgs sectors. This interpretation of early LHC data provides meaningful insights despite statistical limitations.

More Related Videos

Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis

Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis

Published on: March 29, 2016

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Published on: December 3, 2013

Related Experiment Videos

Last Updated: May 18, 2026

Setting Limits on Supersymmetry Using Simplified Models

Setting Limits on Supersymmetry Using Simplified Models

Published on: November 15, 2013

Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis

Quantification of Hydrogen Concentrations in Surface and Interface Layers and Bulk Materials through Depth Profiling with Nuclear Reaction Analysis

Published on: March 29, 2016

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Measurement of Coherence Decay in GaMnAs Using Femtosecond Four-wave Mixing

Published on: December 3, 2013

Area of Science:

High Energy Physics
Particle Physics
Standard Model Physics

Background:

Recent publications from the ATLAS and CMS collaborations present results from Higgs boson searches.
Understanding the properties of the Higgs boson is crucial for testing the Standard Model of particle physics.

Purpose of the Study:

To interpret the results of recent Higgs searches by the ATLAS and CMS experiments.
To determine Higgs boson couplings using published 2011 data.
To extrapolate these findings to various Large Hadron Collider (LHC) running scenarios.

Main Methods:

Analysis of published Higgs search results from ATLAS and CMS.
Interpretation within the framework of standard model effective field theory operators.
Determination of Higgs boson couplings for a mass of 125 GeV.
Extrapolation of results to future LHC running conditions.

Main Results:

Several Higgs couplings were determined from the 2011 data.
Meaningful constraints on modified Higgs sectors were derived.
The analysis, though limited by low statistics, yielded significant insights.

Conclusions:

The interpretation of early Higgs search data provides valuable constraints on the Standard Model.
Future LHC data will further refine these constraints and potentially reveal deviations from the Standard Model.