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Related Experiment Video

Updated: May 18, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

Control parameter description of eukaryotic chemotaxis.

Gabriel Amselem1, Matthias Theves, Albert Bae

  • 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.

Physical Review Letters
|September 26, 2012
PubMed
Summary
This summary is machine-generated.

Chemotaxis in Dictyostelium discoideum relies on signal-to-noise ratio (SNR). The Ueda and Shibata theory accurately predicts cell behavior for low SNR, but requires adjustments for higher SNR values.

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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

Related Experiment Videos

Last Updated: May 18, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
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Published on: November 9, 2017

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

Area of Science:

  • Cellular biology
  • Biophysics
  • Biochemistry

Background:

  • Chemotaxis, the directed movement of cells in response to chemical cues, is crucial for eukaryotic organisms.
  • Cellular response to chemoattractants depends on both average concentration and gradient steepness.
  • The social amoeba Dictyostelium discoideum is a model organism for studying chemotaxis.

Purpose of the Study:

  • To quantitatively test the Ueda and Shibata prediction regarding chemotaxis efficacy in Dictyostelium discoideum.
  • To investigate the role of signal-to-noise ratio (SNR) as a sole control parameter for chemotaxis.
  • To determine the range of applicability for the SNR-based chemotaxis model.

Main Methods:

  • Experimental measurement of chemotaxis in Dictyostelium discoideum.
  • Quantitative analysis of stochastic fluctuations in chemoattractant receptor binding and intracellular signaling.
  • Comparison of experimental data with theoretical predictions based on SNR.

Main Results:

  • The signal-to-noise ratio (SNR) effectively predicts chemotaxis efficacy for Dictyostelium discoideum when SNR is less than or approximately equal to 1.
  • Deviations from the predicted behavior occur at higher SNR values.
  • Additional noise sources downstream in the signaling pathway become significant for larger SNR.

Conclusions:

  • The SNR model provides a good approximation for chemotaxis under low noise conditions.
  • Further investigation is needed to elucidate the impact of downstream noise sources on chemotaxis at higher SNRs.
  • Understanding these noise dynamics is essential for a comprehensive model of eukaryotic cell chemotaxis.