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Updated: May 18, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Anti-microbial activities of sulfonamides using disc diffusion method.

Saba Ahmad¹, Muhammad Akhyar Farrukh

¹Department of Chemistry, Government College University Lahore, Lahore, Pakistan.

Pakistan Journal of Pharmaceutical Sciences

|September 27, 2012

Summary

This summary is machine-generated.

Two novel sulfonamides were synthesized and tested for their effectiveness against various bacteria. These compounds demonstrated significant antimicrobial activity, highlighting their potential for treating bacterial infections.

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Area of Science:

Medicinal Chemistry
Microbiology

Background:

Sulfonamides represent an established class of antimicrobials with broad-spectrum efficacy against Gram-positive and Gram-negative bacteria.
These compounds are frequently employed in treating diverse infections, including malaria, urinary tract infections, and respiratory tract infections.

Purpose of the Study:

To synthesize and characterize two novel sulfonamide derivatives.
To evaluate the antimicrobial potential of these newly synthesized compounds against pathogenic bacterial strains.

Main Methods:

Synthesis of two novel sulfonamides: N-(2-methoxy phenyl)-4-methylbenzenesulfonamide and N-ethyl-4-methyl-N-(3-methyl phenyl)benzenesulfonamide.
Characterization of the synthesized compounds using Fourier-Transform Infrared Spectroscopy (FT-IR) and elemental analysis.
Assessment of antimicrobial activity via the disc diffusion method against both Gram-positive and Gram-negative bacteria.

Main Results:

Successful synthesis and characterization of the two target sulfonamide compounds.
Both novel sulfonamides exhibited notable antimicrobial activity against the tested bacterial strains.
The compounds demonstrated efficacy against a spectrum of Gram-positive and Gram-negative bacteria.

Conclusions:

The synthesized sulfonamide derivatives possess significant antimicrobial properties.
These novel compounds show promise as potential therapeutic agents for bacterial infections.
Further investigation into their mechanism of action and in vivo efficacy is warranted.