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Published on: December 6, 2021
Functionalized graphene-coated cobalt nanoparticles for highly efficient surface-assisted laser desorption/ionization
Hideya Kawasaki1, Keisuke Nakai, Ryuichi Arakawa
1Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan. hkawa@kansai-u.ac.jp
Benzylamine-functionalized graphene-coated cobalt nanoparticles (CoC-NH(2) nanomagnets) efficiently enrich analytes for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). This method enables sensitive detection of environmental pollutants and drugs.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) requires efficient analyte enrichment.
- Developing novel nanomaterials is crucial for enhancing SALDI-MS performance.
- Magnetic nanoparticles offer advantages for analyte separation and enrichment.
Purpose of the Study:
- To develop and characterize graphene-coated cobalt nanoparticles functionalized with benzylamine groups (CoC-NH(2) nanomagnets) for affinity SALDI-MS.
- To evaluate the efficiency of CoC-NH(2) nanomagnets in analyte enrichment and magnetic separation.
- To assess the performance of CoC-NH(2) nanomagnets in the sensitive detection of various analytes using SALDI-MS.
Main Methods:
- Synthesis and characterization of graphene-coated cobalt nanoparticles with benzylamine functionalization.
- Evaluation of nanoparticle properties: mean diameter, specific surface area, and saturation magnetization.
- Application of CoC-NH(2) nanomagnets for magnetic separation and enrichment of analytes.
- Analysis of enriched analytes using surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS).
Main Results:
- CoC-NH(2) nanomagnets exhibited a mean diameter of 30 nm, high specific surface area (15 m(2) g(-1)), and high saturation magnetization (158 emu g(-1)).
- Surface functionalization with benzylamine groups enhanced peptide ion yield and reduced fragmentation of thermometer ions.
- Efficient enrichment and sensitive detection (sub-part-per-trillion level) of perfluorooctanesulfonate were achieved.
- The method demonstrated applicability for detecting environmentally significant compounds like pentachlorophenol, bisphenol A, polyfluorinated compounds (PFCs), and small drugs.
Conclusions:
- CoC-NH(2) nanomagnets are highly effective for analyte enrichment in affinity SALDI-MS.
- The magnetic separation capability of these nanomagnets facilitates efficient sample preparation.
- The developed method offers high sensitivity for detecting trace amounts of various organic compounds and drugs.
