Related Experiment Video
Updated: May 18, 2026
07:08
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
Macular assessment using optical coherence tomography for glaucoma diagnosis.
Kyung Rim Sung1, Gadi Wollstein, Na Rae Kim
1Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul 138-736, Korea. sungeye@gmail.com
The British Journal of Ophthalmology
|September 29, 2012
Summary
Optical coherence tomography (OCT) can assess the macula for glaucoma diagnosis. Combining macular and circumpapillary retinal nerve fibre layer (cpRNFL) measurements may improve glaucoma detection strategies.
Area of Science:
- Ophthalmology
- Medical Imaging
- Glaucoma Research
Background:
- Glaucoma diagnosis relies on optic nerve head and retinal nerve fiber layer measurements.
- Limitations in availability and precision of standard measurements necessitate alternative indicators.
- The macula is a potential alternative site for glaucoma assessment using optical coherence tomography.
Purpose of the Study:
- To evaluate the diagnostic capabilities of macular measurements for glaucoma.
- To compare macular assessment with standard circumpapillary retinal nerve fibre layer (cpRNFL) measurements.
- To explore the potential of combining macular and cpRNFL data for improved glaucoma detection.
Main Methods:
- Utilized time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT) for retinal imaging.
- Analyzed macular structural measurements for glaucoma diagnostic performance.
- Compared macular assessment performance with cpRNFL measurements.
Main Results:
- Macular measurements using TD-OCT demonstrated good glaucoma diagnostic capabilities.
- While cpRNFL measurements were generally superior, macular assessment showed advantages in specific cases.
- SD-OCT enables higher resolution imaging, allowing for segmentation of inner macular layers.
Conclusions:
- Macular measurements can serve as a valuable surrogate for glaucomatous structural assessment.
- Combining macular and cpRNFL measurements may offer a more robust diagnostic strategy.
- Further research into optimizing scanning modes and analytical algorithms for macular OCT is warranted.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...