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Updated: May 18, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Tissue remodeling in eosinophilic esophagitis
Edaire Cheng1, Rhonda F Souza, Stuart J Spechler
1Departments of Pediatrics, Children’s Medical Center, USA.
American Journal of Physiology. Gastrointestinal and Liver Physiology
|September 29, 2012
Summary
Eosinophilic esophagitis (EoE) involves esophageal inflammation and tissue remodeling. Understanding the roles of eosinophils, mast cells, and cytokines may reveal new therapeutic targets for EoE complications.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Eosinophilic esophagitis (EoE) is an immune-mediated esophageal disease.
- It presents with esophageal dysfunction and eosinophil-rich inflammation.
- Chronic inflammation leads to tissue remodeling, causing strictures and fragility.
Purpose of the Study:
- To review the pathogenesis of tissue remodeling in EoE.
- To explore the roles of inflammatory cells and cytokines in remodeling.
- To identify potential therapeutic targets for EoE complications.
Main Methods:
- Review of emerging studies on EoE pathogenesis.
- Analysis of the roles of eosinophils, mast cells, and cytokines.
- Investigation of profibrotic cytokines like IL-4, IL-13, and TGF-β1.
Main Results:
- Eosinophil and mast cell secretory products contribute to remodeling.
- Th2 cytokines (IL-4, IL-13) and TGF-β1 promote fibrosis and epithelial-mesenchymal transition.
- These factors regulate periostin, influencing extracellular matrix.
Conclusions:
- Fibroblasts, eosinophils, mast cells, and cytokines are key players in EoE esophageal remodeling.
- Targeting these components may offer future therapies for EoE complications.
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