Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Impact of Next-Generation Sequencing on Interobserver Agreement and Diagnostic Accuracy of Deep Penetrating Melanocytic Neoplasms.

Journal of cutaneous pathology·2025

Same author

WHO classification of skin tumours: key updates in the fifth edition.

Histopathology·2025

Same author

Dr. Martin C. Mihm Jr., My Mentor, My Friend, My Family.

Journal of cutaneous pathology·2025

Same author

The Twentieth Century Dermatopathologist Who Revolutionized the Discipline.

Journal of cutaneous pathology·2025

Same author

Minimum Pathology Reporting Elements for Melanoma: A Review of Reporting Guidelines and Proposal for Minimum Reporting Elements for a Quality Pathology Report by the Task Force of the American Society of Dermatopathology.

Journal of cutaneous pathology·2025

Same author

Concordance Between a Mohs Micrographic Surgeon and Dermatopathologist on Margin Status for Melanoma In Situ and the Role of Immunohistochemical Stains.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]·2025

Search research articles

Related Experiment Video

Updated: May 18, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Melanoma staging: where are we now?

Adriano Piris¹, Alice Coelho Lobo, Lyn M Duncan

¹Dermatopathology Unit, Pathology Service, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, WRN 820, Boston, MA 02114, USA.

Dermatologic Clinics

|October 2, 2012

Summary

The 2009 AJCC Melanoma Staging guidelines feature significant revisions based on extensive patient data. These updates refine melanoma classification and TNM categories for improved accuracy.

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Related Experiment Videos

Last Updated: May 18, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Oncology
Dermatology

Background:

The American Joint Committee on Cancer (AJCC) Melanoma Staging guidelines are crucial for classifying melanoma severity.
Previous versions of the AJCC guidelines have been updated periodically to reflect new research.

Purpose of the Study:

To summarize the key findings and new definitions in the 2009 AJCC Melanoma Staging and Classification system.
To outline the changes implemented in the seventh version of the AJCC melanoma staging system.

Main Methods:

Analysis of the largest melanoma patient cohort to date.
Multivariate analysis of 30,946 patients with stages I-III melanoma and 7972 patients with stage IV melanoma.
Review of the TNM categories and stage groupings defined in the 2009 guidelines.

Main Results:

The 2009 AJCC Melanoma Staging guidelines incorporate significant revisions compared to prior versions.
The updated schema is based on a comprehensive analysis of over 38,000 melanoma patients.
New definitions for TNM categories and stage groupings have been established.

Conclusions:

The 2009 AJCC Melanoma Staging system represents a substantial advancement in melanoma classification.
These revisions are based on robust data analysis, aiming for more accurate patient stratification.
The updated guidelines provide a refined framework for understanding and managing melanoma progression.