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Updated: May 18, 2026
The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
Published on: November 2, 2016
Tumor vascular responses to antivascular and antiangiogenic strategies: looking for suitable models
Jihane Mriouah1, Cédric Boura, Magalie Thomassin
1Université de Lorraine, CRAN, UMR 7039, Vandœuvre-lès-Nancy, France.
Abstract:
Antiangiogenic and vascular disrupting agents are in the current cancer therapeutic armamentarium. A better understanding of the intricate mechanisms ruling neovessel survival within tumors during or after treatment is needed. Refinement of imaging and a growing knowledge of molecular biology of tumor vascularization provide new insights. It is necessary to define suitable methods for monitoring tumor response and appropriate tools to analyze data. This review compares most commonly used preclinical models, considering their recent improvements, and describes promising new approaches such as microfluidics, real-time electrical impedance based technique and noninvasive imaging techniques. The advantages and limitations of the in vitro, ex vivo and in vivo models are discussed. This review also provides a critical summary of emerging approaches using mathematical modeling.
Insights
Understanding tumor neovessel survival is crucial for cancer therapy. This review examines preclinical models and new techniques like microfluidics and advanced imaging for monitoring antiangiogenic and vascular disrupting agent efficacy.
Area of Science:
- Oncology
- Vascular Biology
- Biomedical Engineering
Background:
- Antiangiogenic and vascular disrupting agents are key cancer therapies.
- Tumor neovessel survival mechanisms require further elucidation for treatment optimization.
- Advances in imaging and molecular biology offer new perspectives on tumor vascularization.
Purpose of the Study:
- To review and compare preclinical models for studying tumor vascularization.
- To describe emerging techniques for monitoring tumor response to vascular-targeting therapies.
- To critically evaluate the utility of mathematical modeling in this field.
Main Methods:
- Comparison of in vitro, ex vivo, and in vivo preclinical models.
- Description of novel techniques including microfluidics and real-time electrical impedance.
- Review of noninvasive imaging modalities.
- Analysis of mathematical modeling approaches.
Main Results:
- Current preclinical models have limitations but are continually improving.
- New approaches offer enhanced capabilities for studying tumor vascularization and treatment response.
- A combination of techniques may be necessary for comprehensive analysis.
Conclusions:
- Refined preclinical models and novel monitoring tools are essential for advancing cancer therapy.
- Integrating diverse methodologies, including mathematical modeling, can improve understanding of tumor vascular biology.
- Further research is needed to validate and implement these emerging approaches in clinical settings.
