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Updated: May 18, 2026
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
Ultrasensitive and facile electrochemical deoxyribonucleic acid biosensor based on the conformational change of the
Wei Chen1, Yin-Huan Liu, Hong-Na Li
1Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China. chenandhu@163.com
Abstract:
An ultrasensitive electrochemical impedance spectroscopic deoxyribonucleic acid biosensor has been developed based on the conformational change of the deoxyribonucleic acid recognition interface with lodging probes. Pairing process leads to desorption of deoxyribonucleic acid bases from the gold surface, leading to a significant change of the interfacial conformation and the charge transfer resistance. Remarkably low detection limits down to 40 fM are thus obtained without any additional amplification step.
