Related Experiment Video
Updated: May 18, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
A nonhuman primate model of stable urinary sphincter deficiency
Sherif Badra1, Karl-Erik Andersson, Ashley Dean
1Wake Forest Institute for Regenerative Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27101, USA.
The Journal of Urology
|October 2, 2012
Summary
Researchers developed a nonhuman primate model for urinary sphincter deficiency, showing significant pressure loss and nerve response reduction post-injury. This model aids in studying incontinence pathophysiology and testing new therapies.
Area of Science:
- Urology
- Animal Models
- Neuroscience
Background:
- Urinary sphincter deficiency in women lacks full understanding, and treatments are limited.
- Female nonhuman primates offer a relevant model due to physiological and anatomical similarities to humans.
Purpose of the Study:
- To develop and characterize a nonhuman primate model of urethral sphincter complex injury.
- To investigate the pathophysiology of urinary sphincter deficiency.
Main Methods:
- 22 female cynomolgus monkeys underwent pudendal nerve injury to the sphincter complex.
- Urodynamic studies and cystourethrography were performed pre- and post-injury (3, 6, 12 months).
- Quantitative histology and immunohistochemistry analyzed sphincter structure and innervation.
Main Results:
- Maximal urethral pressure decreased by 47-50% post-injury.
- Responses to nerve stimulation were abolished for over 12 months.
- Urodynamic changes correlated with reduced muscle and nerve components in the sphincter.
Conclusions:
- The induced changes mimic those seen in women with stress urinary incontinence.
- Nonhuman primates serve as effective models for studying urinary sphincter deficiency.
- This model is valuable for testing novel therapeutic interventions.
