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Visual specific luminescent probing of hybrid G-quadruplex DNA by a ruthenium polypyridyl complex

Guo-Liang Liao1, Xiang Chen, Liang-Nian Ji

  • 1MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, PR China.

Chemical Communications (Cambridge, England)
|October 2, 2012
PubMed

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DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...