Related Experiment Video
Updated: May 18, 2026
09:52
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
[Ototoxicity of cisplatin]
Vestnik Otorinolaringologii
|October 5, 2012
Summary
This review covers cisplatin ototoxicity, detailing its causes, symptoms, and prevention strategies. It highlights shared and unique mechanisms of inner ear damage from drugs, emphasizing genetic risk factors.
Area of Science:
- Ototoxicology
- Pharmacology
- Genetics
Context:
- Cisplatin is a widely used chemotherapy agent.
- Ototoxicity is a significant dose-limiting side effect of cisplatin.
- Understanding cisplatin's impact on the inner ear is crucial for patient management.
Purpose:
- To summarize current knowledge on cisplatin ototoxicity.
- To explore the pathogenesis and clinical manifestations of cisplatin-induced inner ear damage.
- To review screening, prophylaxis, and otoprotection strategies.
Summary:
- Cisplatin ototoxicity shares mechanisms with other ototoxic drugs but has unique features.
- Cytotoxicity, risk factors, and genetic predisposition influence cisplatin-induced inner ear injury.
- The publication discusses monitoring and experimental otoprotection for auditory damage.
Impact:
- Provides a comprehensive overview of cisplatin ototoxicity for researchers and clinicians.
- Informs strategies for mitigating hearing loss in cancer patients undergoing cisplatin treatment.
- Highlights the importance of personalized medicine considering genetic factors in ototoxicity.
Related Concept Videos
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
02:52Stereoisomerism
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
01:24Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...