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Efficacy of Single and Fractionated Neutron Irradiation of Normal and Tumor Cells In Vitro
E V Koryakina1, A A Pichkunova2, M V Troshina2
1A. Tsyb Medical Radiological Research Center - Branch of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia. ek-koryakina@mrrc.obninsk.ru.
Abstract:
We studied the effect of 14.5 MeV neutron dose ultrafractionation on survival and recovery kinetics from radiation damage in normal V-79 and tumor B14-150 cells. Neutron doses of 0.5, 2, 4, and 6 Gy were split into 1, 2, 3, and 4 fractions. The observed recovery times 1.6 h (V-79) and 0.94 h (B14-150) indicate the possibility of reducing radiation damage with increasing the number of fractions. It was shown that neutron irradiation efficacy decreases when intervals between fractions exceed 1 h.
