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Total synthesis of (-)-tirandamycin C utilizing a desymmetrization protocol
J S Yadav1, Santu Dhara, Sk Samad Hossain
1Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadavpub@iict.res.in
The Journal of Organic Chemistry
|October 9, 2012
Abstract:
A highly stereoselective total synthesis of (-)-tirandamycin C has been achieved following a desymmetrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed ketalization, Still-Gennari (Z)-selective olefination, and Dieckmann cyclization as key reactions.
