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Viridin analogs derived from steroidal building blocks
Kishore Viswanathan1, Sophia N Ononye, Harold D Cooper
1Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT 06269, United States.
Abstract:
Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex natural products from abundant steroid feedstock materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast cancer line.
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