Gastroparesis.

Area of Science:

• Gastroenterology
• Clinical Medicine
• Digestive Physiology

Background:

• Gastroparesis is characterized by delayed gastric emptying without mechanical blockage.
• It significantly impacts patients' quality of life through symptoms like nausea and vomiting.
• Recent years have seen substantial progress in understanding its complex pathophysiology.

Purpose of the Study:

• To provide an updated review of gastroparesis.
• Focus on new findings and insights from the past few years.
• Synthesize current knowledge on clinical features, pathophysiology, diagnosis, and therapy.

Main Methods:

• Review of recent large database studies and histologic investigations.
• Analysis of advancements in gastric emptying testing.
• Evaluation of emerging therapeutic strategies and ongoing research.

Main Results:

• Characterization of clinical profiles in idiopathic and diabetic gastroparesis.
• Clarification of dietary deficiencies and identification of histologic abnormalities in severe cases.
• Introduction of novel diagnostic methods like wireless motility capsules and new therapeutic agents including prokinetics and antiemetics.

Conclusions:

• Significant progress has been made in understanding gastroparesis causes, presentation, and management.
• Ongoing research promises further advancements in diagnosis and treatment.
• Improved glycemic control is crucial for managing diabetic gastroparesis.