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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates
Mohd Aftab Alam1, Raisuddin Ali, Fahad Ibrahim Al-Jenoobi
1King Saud University, College of Pharmacy, PO Box 2457, Riyadh 11451, Saudi Arabia. afealam@rediffmail.com
Expert Opinion on Drug Delivery
|October 10, 2012
Summary
Solid dispersions (SDs) offer stable amorphous formulations for poorly soluble drugs. Incorporating surfactants and polymers into SDs enhances drug solubility and prevents recrystallization, improving pharmaceutical stability.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Solid dispersion (SD) technologies are crucial for developing stable amorphous pharmaceutical formulations.
- Patented inventions focus on enhancing the stability of amorphous solid dispersions.
Purpose of the Study:
- To review solid dispersion technologies and patented inventions for stable amorphous SDs.
- To explore preparation techniques, applications, characterization, and carriers for SDs.
Main Methods:
- Compilation of various SD preparation techniques and characterization methods.
- Summary of advantages of advanced SD technologies like RightSize(™), CSD, and Lidose®.
- Discussion of stability issues (phase separation, recrystallization) and mitigation strategies.
Main Results:
- Binary and ternary solid dispersions demonstrate superior stability and solubility enhancement for poorly water-soluble drugs.
- The use of surfactants in carrier systems is a recent trend, improving stability and dissolution.
- Advanced carriers like Soluplus®, Neusilin®, and Solumer(TM) are effective for stable amorphous SDs.
Conclusions:
- Solid dispersions, particularly binary and ternary systems with surfactants and polymers, significantly improve drug solubility and dissolution.
- These formulations offer enhanced physical stability, preventing recrystallization and phase separation.
- SD technology is applicable in controlled drug delivery and cosmetic applications.
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