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A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

Structural and functional concepts in current mouse phenotyping and archiving facilities.

Heike Kollmus¹, Rainer Post, Markus Brielmeier

¹Helmholtz Centre for Infection Research, Braunschweig, Germany.

Journal of the American Association for Laboratory Animal Science : JAALAS

|October 10, 2012

Summary

This summary is machine-generated.

Designing new animal research facilities requires analyzing existing infrastructure. While a universal strategy is lacking due to specific needs, common functional concepts for mouse phenotyping and archiving facilities can guide new constructions.

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Area of Science:

Comparative biology
Laboratory animal science
Research infrastructure development

Background:

Planning new animal experimental research units necessitates understanding existing facility designs and workflows.
The European Infrafrontier project aims to create a unified European infrastructure for high-throughput mouse model phenotyping, archiving, and dissemination.

Purpose of the Study:

To collect and analyze building plans, concepts, and workflows from existing animal research facilities.
To identify common principles and diverse strategies in the design of animal research facilities for future planning.

Main Methods:

Expert visits to nine research facilities and three commercial breeders across Europe, Canada, the United States, and Singapore.
Detailed data collection, including standardized floor plans and descriptive tables, for each visited facility.

Main Results:

No single common strategy exists for constructing animal facilities due to varying local needs, property constraints, and legal regulations.
Several fundamental concepts and standardized floor plans illustrating principal functional units and their interconnections were identified.

Conclusions:

Individual facilities employ unique concepts to meet specific scientific and regulatory requirements.
The analysis provides valuable insights for research centers planning new mouse phenotyping and archiving facilities.