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Case for diagnosis. Adult-type xanthogranuloma
Felipe Maurício Soeiro Sampaio1, Fabrício Tinoco Lourenço, Daniel Lago Obadia
1Department of Tropical Dermatology, Hospital Central do Exército, Benfica, RJ, Brazil. felipemauricio@uol.com.br
Anais Brasileiros De Dermatologia
|October 10, 2012
Summary
A solitary xanthogranuloma was diagnosed in a 28-year-old male based on histopathology and immunohistochemistry. The asymptomatic skin lesion required only patient orientation due to its isolated nature.
Area of Science:
- Dermatopathology
- Histopathology
- Immunohistochemistry
Background:
- Xanthogranuloma is a rare non-Langerhans cell histiocytosis.
- Adult-type xanthogranuloma (AXG) typically presents as a solitary lesion.
Observation:
- A 28-year-old male presented with an asymptomatic yellowish-red papule on his thigh.
- Histopathological examination revealed multinucleated Touton giant cells.
- Immunohistochemistry showed S100 negativity, CD1a negativity, CD4 positivity, and CD68 positivity.
Findings:
- The clinical and histopathological features, along with immunohistochemical markers, confirmed the diagnosis of adult-type xanthogranuloma.
- The lesion was characterized by specific cellular morphology and marker expression.
Implications:
- Solitary adult-type xanthogranuloma is a benign condition.
- Management involves observation when the lesion is isolated and asymptomatic.
- This case highlights the diagnostic utility of combining clinical, histological, and immunohistochemical data.
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