Two new neolignan glucosides from Arctii Fructus

Area of Science:

• Phytochemistry
• Natural Product Chemistry

Background:

• Arctii Fructus (Burdock fruit) is a traditional medicinal herb.
• Natural products research aims to discover novel bioactive compounds.

Purpose of the Study:

• To isolate and characterize new chemical constituents from Arctii Fructus.
• To elucidate the structures and absolute configurations of these compounds.

Main Methods:

• Extraction from Arctii Fructus.
• Isolation of compounds using chromatographic techniques.
• Structure elucidation via spectroscopic methods including IR, HR-ESI-MS, 1D and 2D NMR, and CD analysis.

Main Results:

• Two new neolignan glucosides were identified: (7S, 8R)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxyl-7'-oxo-8-4'-oxyneolignan-4-O-β-D-glucopyranoside and (7'S, 8'R, 8S)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-O-β-D-glucopyranosyl-4'-O-β-D-glucopyranoside.
• Two known small molecular peptides, 3-benzyl-6-(1-hydroxyethyl)-2,5-piperazinedione and 3-benzyl-2,5-piperazinedione, were also isolated.
• The structures and absolute configurations were confirmed through comprehensive spectroscopic analysis.

Conclusions:

• The study successfully identified and characterized four compounds from Arctii Fructus, including two novel neolignan glucosides.
• The findings contribute to the understanding of the chemical diversity of Arctii Fructus.
• These isolated compounds may serve as leads for further pharmacological investigations.