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Aplastic anemia: a common hematological abnormality among peripheral pancytopenia
Haldar Biswajit1, Pal Partha Pratim, Sarkar Tarun Kumar
1Department of Pathology, North Bengal Medical College, Darjeeling, India.
North American Journal of Medical Sciences
|October 11, 2012
Summary
Aplastic anemia, a form of marrow failure, is a common hematological issue in North Bengal. This study found males were more frequently affected, with disease severity potentially linked to age.
Area of Science:
- Hematology
- Internal Medicine
Background:
- Aplastic anemia is a recognized cause of bone marrow failure, with variable incidence.
- While most cases are acquired and immune-mediated, inherited forms also exist.
Purpose of the Study:
- To evaluate the prevalence, morphological characteristics, and contributing factors of aplastic anemia in North Bengal.
- To understand the scope of aplastic anemia in the specified region.
Main Methods:
- A cross-sectional study was conducted over one year.
- Participants aged 5 to 70 years underwent complete blood count and bone marrow examination for diagnosis.
Main Results:
- Out of 48 cases, 79.17% were diagnosed with aplastic anemia (hypocellular bone marrow).
- Histopathology revealed increased iron stores in 78.95% of cases.
- Younger individuals (<20 years) predominantly had non-severe disease, while older groups had severe or very severe disease, though not statistically significant.
Conclusions:
- Aplastic anemia is a prevalent hematological abnormality in North Bengal, particularly among individuals with peripheral pancytopenia.
- Males were observed to be more affected than females in this region.
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