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Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Updated: May 17, 2026

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
10:21

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Updates on the COPD gene list.

Yohan Bossé1

  • 1Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada. yohan.bosse@criucpq.ulaval.ca

International Journal of Chronic Obstructive Pulmonary Disease
|October 12, 2012
PubMed
Summary
This summary is machine-generated.

Genetic factors influence chronic obstructive pulmonary disease (COPD) risk. This review compiles known COPD genes and recent genetic discoveries, aiding future research into this complex respiratory disease.

Keywords:
COPDcandidate genesgeneticsgenome-wide association studylung function

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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification
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Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

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Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
09:52

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)

Published on: April 19, 2013

Area of Science:

  • Pulmonary Medicine
  • Genetics
  • Genomics

Background:

  • Genetic predisposition is a known factor in chronic obstructive pulmonary disease (COPD) development.
  • Specific genes contributing to COPD risk and varying susceptibility to smoke exposure are not fully understood.

Purpose of the Study:

  • To provide a comprehensive literature review on COPD genetics.
  • To highlight recent advancements in COPD genetic research.
  • To present an updated list of genes associated with COPD.

Main Methods:

  • Systematic literature search of candidate gene studies for COPD and related phenotypes in PubMed (pre-January 5, 2012).
  • Tabulation of candidate gene studies and associated publications.
  • Summary of recent genetic loci identified through genome-wide association studies (GWAS) for COPD, lung function, and related complications.

Main Results:

  • A comprehensive list of candidate genes implicated in COPD has been compiled.
  • Recent genetic loci from GWAS studies have been summarized.
  • The review consolidates existing knowledge and identifies areas for future investigation.

Conclusions:

  • An updated COPD gene list and summary of GWAS findings are provided.
  • The compiled resources are valuable for future replication studies, meta-analyses, and genomic data reanalysis.
  • Integrative genomic approaches and large-scale studies are crucial for understanding the genetic basis of COPD.