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Updated: May 17, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and in vitro antimicrobial study of 4-thiazolidinone containing sulfanilamide
Augusta Zevzikoviene1, Andrejus Zevzikovas, Eduardas Tarasevicius
1Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Kaunas, Lithuania. augustazev@gmail.com
Abstract:
The title compounds, 3-allyl-2-sulfanylamido-4-thiazolidinones (2a-d), have been synthesized after substitution of amino group of sulfanylamide with allylisothiocyanate and cyclization into 4-thiazolidinones. The synthesized compounds were tested for their antibacterial and antifungal activity (MIC) in vitro) against microorganisms: S. aureus, E. faecalis. E. coli, P. aeruginosa, K. pneumoniae, P. mirabilis, B. subtilis, B. cereus and C. albicans taking sulfadimidine, sulfathiazole, sulfanilamide and sulfamethizole as standard drugs. Synthesized compounds (2a-d) demonstrated selective activity against B. cereus.
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