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Updated: May 17, 2026
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Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Cytogenetic abnormalities precede morphological abnormalities in developing malignant conditions: report of 2 cases
Wendy A Symons1, Frederick L Flynt, Christina Mendiola
1Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, United States.
Experimental and Molecular Pathology
|October 16, 2012
Summary
Cytogenetic abnormalities, or changes in chromosomes, can appear before physical signs of cancer emerge. This study presents two cases where genetic changes were found in morphologically normal samples, supporting this hypothesis in malignant conditions.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Malignant conditions often involve complex genetic alterations.
- The temporal relationship between cytogenetic and morphological abnormalities in cancer development is a key area of research.
- Previous studies suggested genetic changes precede physical manifestations of cancer.
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