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Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

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Related Experiment Video

Updated: May 17, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
08:30

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Updates on Von Willebrand Disease Testing.

Eric Salazar1, Russell A Higgins1

  • 1Department of Pathology and Laboratory Medicine, UT Health San Antonio, San Antonio, TX, USA.

Clinics in Laboratory Medicine
|May 15, 2026
PubMed
Summary
This summary is machine-generated.

Von Willebrand Disease (VWD) diagnosis is evolving. Newer lab tests offer better accuracy than traditional methods for identifying von Willebrand Factor (VWF) deficiencies.

Keywords:
Coagulation testingLaboratory testingVon Willebrand disease

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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Related Experiment Videos

Last Updated: May 17, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow
11:42

Live-cell Imaging of Platelet Degranulation and Secretion Under Flow

Published on: July 10, 2017

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Area of Science:

  • Hematology
  • Clinical Diagnostics
  • Genetics

Background:

  • Von Willebrand Disease (VWD) is the most prevalent inherited bleeding disorder globally.
  • It stems from quantitative or qualitative defects in von Willebrand Factor (VWF).
  • VWF is crucial for primary hemostasis and stabilizing Factor VIII.

Purpose of the Study:

  • To review recent advancements in the diagnostic approaches for VWD.
  • To highlight innovations improving the accuracy and classification of VWD subtypes.

Main Methods:

  • Integration of patient bleeding history with laboratory testing.
  • Utilization of novel laboratory assays like VWF:GPIbM and VWF:GPIbR.
  • Application of advanced multimer analysis, collagen binding assays, and genetic testing.

Main Results:

  • Newer diagnostic methods demonstrate improved analytical performance over traditional assays like ristocetin cofactor activity (VWF:RCo).
  • These innovations enhance the precision in classifying different VWD subtypes.
  • Genetic testing provides further refinement in diagnostic capabilities.

Conclusions:

  • The diagnosis of VWD benefits significantly from integrating clinical data with advanced laboratory diagnostics.
  • Emerging technologies are transforming VWD testing, leading to more accurate subtyping and management.
  • Continued adoption of these innovative methods is essential for optimal patient care.