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Emerging invasive fungal diseases in transplantation

Perrine Parize1, Blandine Rammaert, Olivier Lortholary

  • 1Université Paris-Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Service des Maladies Infectieuses et Tropicales, APHP, Centre d'Infectiologie Necker-Pasteur, Institut Hospitalo-Universitaire Imagine, 149, rue de Sèvres, 75743, Paris Cedex 15, France.

Current Infectious Disease Reports
|October 16, 2012
PubMed

Insights

Invasive fungal infections pose significant risks for transplant recipients. This review highlights recent trends in their epidemiology, diagnosis, and treatment for immunocompromised patients.

Area of Science:

  • Medicine
  • Infectious Diseases
  • Transplant Science

Background:

  • Invasive fungal infections (IFIs) are a leading cause of death in transplant recipients.
  • Candida and Aspergillus species are common, but other fungi are emerging.
  • Diagnosing and treating IFIs in transplant patients remains difficult.

Purpose of the Study:

  • To review emerging topics in IFIs in transplantations from 2011-2012.
  • To synthesize new trends in epidemiology, outbreaks, clinical findings, and diagnostics.
  • To discuss advances in therapeutic resources for IFIs.

Main Methods:

  • Literature review of studies published between 2011 and 2012.
  • Synthesis of data on epidemiology, outbreaks, clinical presentations, and management.
  • Focus on trends in invasive fungal infections in transplant medicine.

Main Results:

  • Emerging fungal pathogens are increasingly prevalent in transplant recipients.
  • Recent outbreaks and shifts in epidemiology were identified.
  • Advances in diagnostic tools and antifungal therapies are noted.

Conclusions:

  • IFIs remain a critical concern in immunocompromised transplant patients.
  • Continuous monitoring of fungal epidemiology and treatment strategies is essential.
  • Further research is needed to combat the evolving challenges of IFIs in transplantation.

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