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Updated: May 17, 2026

07:11
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Recent trends in Cys- and Ser/Thr-based synthetic strategies for the elaboration of peptide constructs
Jean-Christophe M Monbaliu1, Alan R Katritzky
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, 32611-7200, USA.
Abstract:
Recent conceptual advances in the chemical synthesis of peptide constructs are described, encompassing native chemical ligation (i.e. the chemoselective covalent condensation of unprotected peptide segments) and O-, S-acyl isopeptide strategies (i.e. internal O,S-to-N acyl transfer within peptides).

