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Updated: May 17, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
[Expression of parafibromin in human osteosarcoma of the jaws]
Zi-han Sima1, Yan Chen, Tie-jun Li
1Department of Pathology, Peking University School and Hospital of Stomatology, Beijing,China.
Objective:
To investigate the expression of parafibromin in osteosarcoma of the jaws (JOS) and to explore its effects on tumorigenesis and progression.
Methods:
The expression of parafibromin was studied in 47 JOS and 11 ossifying fibroma of the jaws (JOF) by immunohistochemically staining.
Results:
In JOS, the high, medium and low levels of parafibromin expression were detected in 48.9% (23/47), 40.4% (19/47) ,and 10.7% (5/47) of the cases, respectively; correspondingly, the different expressions were seen in 90.9% (10/11), 9.1% (1/11), and 0.0% (0) JOF cases respectively. The difference between JOS and JOF groups was significantly different (U=147.5,P=0.012). In highly differentiated JOS, the expression of parafibromin was significantly higher than that in the conventional JOS (U=71.0,P=0.021) but there were no statistically correlations between the expression of parafibromin and clinical-pathological parameters of JOS (P>0.05).
Conclusion:
It is possible that the down-regulation of parafibromin may be associated with the differentiation and malignant degree of JOS.
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