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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Donor-derived infection: epidemiology and outcomes
1Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical School, 3120 Taubman Center; 1500 E. Medical Center Dr., SPC 5378, Ann Arbor, MI, 48109-5378, USA, kauld@umich.edu.
Current Infectious Disease Reports
|October 18, 2012
Summary
Unexpected infections from organ donors, including HIV and hepatitis C, are rare but serious. This review covers their epidemiology, outcomes, and prevention strategies to enhance solid organ transplant safety.
Area of Science:
- Transplantation Medicine
- Infectious Diseases
- Public Health
Background:
- Solid organ transplantation faces challenges with unexpected infectious pathogen transmission from donors.
- Recent transmissions of human immunodeficiency virus (HIV) and hepatitis C highlight the need for improved safety measures.
Purpose of the Study:
- To review the epidemiology and outcomes of unexpected donor-derived infections in solid organ transplantation.
- To discuss current reporting and patient safety processes.
- To explore preventative measures to mitigate donor-derived infections.
Main Methods:
- Literature review of epidemiology and outcomes of donor-derived infections.
- Analysis of reporting and patient safety protocols.
- Synthesis of evidence on preventative strategies.
Main Results:
- Unexpected donor-derived infections, though uncommon, can have severe consequences, including transmission of HIV and hepatitis C.
- Recent cases underscore the vulnerability of the transplant process to infectious agents.
- Effective reporting and safety protocols are crucial for managing these events.
Conclusions:
- Enhancing the safety of solid organ transplantation requires a comprehensive approach to preventing and managing donor-derived infections.
- Continued vigilance, improved screening, and robust safety processes are essential.
- Preventative measures can significantly reduce the risk and burden of these infections.
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