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Updated: May 17, 2026

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Anaphylactic reaction following administration of nose drops containing benzalkonium chloride
Elke Mezger1, Olaf Wendler, Susanne Mayr
1Department of Otorhinolaryngology-Head and Neck Surgery, University of Erlangen, Germany. Elke.mezger@uk-erlangen.de
Abstract:
We describe a case of anaphylactic reaction in a 46-year-old female post application of decongestant nose drops containing benzalkonium chloride (BAC). With some latency, the patient complained of cough, dyspnea, sensation of heat, croakiness and pruritus. Since she showed all of these symptoms, typical of an anaphylactic reaction, we proceeded some weeks later with a prick test with solutions containing BAC, a cationic surfactant commonly used as an antibacterial preservative in many medical solutions. The prick test was positive, confirming the assumption of a hypersensitive reaction to BAC.
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