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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
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Electroactive tetrathiafulvalenyl-1,2,3-triazoles by click chemistry: Cu- versus Ru-catalyzed azide-alkyne

Thomas Biet1, Thomas Cauchy, Narcis Avarvari

  • 1LUNAM Université, CNRS UMR 6200, Laboratoire MOLTECH-Anjou, 2 bd Lavoisier, 49045 Angers, France.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|October 20, 2012
PubMed

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
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