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Related Experiment Videos

Microencapsulation using poly (L-lactic acid) II: Preparative variables affecting microcapsule properties.

R Jalil1, J R Nixon

  • 1Chelsea Department of Pharmacy, King's College London, UK.

Journal of Microencapsulation
|January 1, 1990
PubMed
Summary
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Poly (L-lactic acid) [L-PLA] microcapsules containing phenobarbitone were formulated using a w/o emulsion. Emulsifier structure, not HLB, significantly impacted microcapsule size, with polymer concentration also playing a key role.

Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Polymer Science

Background:

  • Poly (L-lactic acid) [L-PLA] microcapsules are utilized for drug delivery.
  • Phenobarbitone is an active pharmaceutical ingredient requiring controlled release.
  • Microencapsulation techniques influence drug bioavailability and efficacy.

Purpose of the Study:

  • To investigate the preparation of Poly (L-lactic acid) [L-PLA] microcapsules containing phenobarbitone.
  • To determine the impact of various formulation parameters on microcapsule size and characteristics.
  • To correlate emulsifier properties with microcapsule size in a w/o emulsion system.

Main Methods:

  • Preparation of Poly (L-lactic acid) [L-PLA] microcapsules via a water-in-oil (w/o) emulsion system.

Related Experiment Videos

  • Utilized light liquid paraffin as the continuous phase and acetonitrile as the disperse phase.
  • Varied stirring rate, emulsifier concentration, emulsifier structure, and polymer concentration.

    • Main Results:

    • Increased stirring rate and emulsifier concentration reduced microcapsule size.
    • Emulsifier structure, specifically molecular packing at the interface, influenced microcapsule size, not HLB.
    • Higher polymer concentration, with increased solid content, led to larger microcapsules.
    • Phenobarbitone content remained stable despite variations in preparative parameters.

    Conclusions:

    • Microcapsule size is controllable by adjusting stirring rate, emulsifier concentration, and polymer concentration.
    • Emulsifier molecular structure is a critical factor in determining microcapsule size in this w/o system.
    • The developed method allows for the preparation of phenobarbitone-loaded L-PLA microcapsules with consistent drug content.