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Prenatal detection of simian crease
1Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2675.
Summary
Prenatal ultrasound can detect simian creases, a single transverse palmar line. This finding was observed in fetuses with trisomy 21 and other genetic or structural anomalies.
Area of Science:
- Prenatal diagnosis
- Medical imaging
- Genetics
Background:
- A simian crease, or single transverse palmar line, is a common finding.
- Its association with chromosomal abnormalities and other fetal anomalies is recognized.
Purpose of the Study:
- To present the prenatal detection of simian creases using ultrasound.
- To correlate this finding with fetal chromosomal status and other anomalies.
Main Methods:
- Ultrasound examination for prenatal detection of fetal anomalies.
- Karyotyping for chromosomal analysis.
Main Results:
- Seven fetuses with simian creases were identified prenatally.
- Three of these fetuses had trisomy 21.
- Four fetuses had normal chromosomes but presented with other anomalies, including meningomyelocele and skeletal dysplasias.
Conclusions:
- Prenatal detection of a simian crease is feasible via ultrasound.
- The presence of a simian crease warrants further investigation for trisomy 21 and other fetal anomalies.