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Updated: May 17, 2026

Murine Prostate Micro-dissection and Surgical Castration
Published on: May 11, 2016
Biology of castration-recurrent prostate cancer
1Department of Urology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. faris.azzouni@roswellpark.org
Abstract:
Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.
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