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CRISPR

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...

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Related Experiment Video

Updated: May 17, 2026

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

[Preimplantation genetic diagnosis--developments to expect?].

¹Laboratoire de biologie de la reproduction, unité de diagnostic préimplantatoire, CMCO, 19, rue Louis-Pasteur, 67303 Schiltigheim cedex, France. philippe.gosset@chru-strasbourg.fr

Gynecologie, Obstetrique & Fertilite

|October 23, 2012

Summary

Preimplantation genetic diagnosis (PGD) prevents genetic diseases by selecting healthy embryos. PGD applications are expanding globally, including for stem cell therapies and avoiding late-onset disease transmission.

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Area of Science:

Reproductive medicine
Medical genetics
Bioethics

Context:

Preimplantation genetic diagnosis (PGD) has been established for over two decades.
PGD is utilized to prevent the birth of children with severe genetic disorders.
Current PGD practices aim to identify mutations and HLA typing for therapeutic stem cell transplantation.

Purpose:

To review the evolution and expanding applications of PGD.
To discuss the extension of PGD indications in France for therapeutic purposes and late-onset disease prevention.
To explore potential future uses of PGD, such as Down's syndrome screening.

Summary:

PGD enables the selection of healthy embryos, preventing the transmission of genetic diseases.
French PGD practices now include HLA typing for stem cell sourcing and avoiding transmission of late-onset conditions.
Technological advancements may allow for more complex PGD, including screening for multiple diseases and conditions like Down's syndrome.

Impact:

PGD offers a method to ensure healthier offspring and provides avenues for life-saving stem cell therapies.
The expansion of PGD raises discussions on ethical considerations, regulatory frameworks, and technological limitations.
Future PGD applications hold potential for broader genetic screening and disease prevention, necessitating careful ethical and regulatory evaluation.