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Updated: May 17, 2026
11:06
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Allopurinol-induced hepatomegaly
1Department of Care of the Elderly, Royal London Hospital, London, UK. lucychilds@doctors.org.uk
BMJ Case Reports
|October 23, 2012
Summary
Allopurinol can cause liver damage, though severe cases are uncommon. This case highlights hepatomegaly and abdominal symptoms in an elderly patient due to long-term allopurinol use.
Area of Science:
- Hepatology
- Clinical Pharmacology
Background:
- Allopurinol is a widely used medication for managing hyperuricemia and gout.
- Hepatotoxicity is a known, albeit rare, adverse effect associated with allopurinol therapy.
Observation:
- A case study involving an elderly woman with a history of long-term allopurinol use.
- The patient presented with abdominal symptoms indicative of liver enlargement.
Findings:
- The patient developed allopurinol-induced hepatomegaly.
- This liver condition manifested as significant abdominal discomfort.
Implications:
- This case underscores the importance of monitoring liver function in patients on long-term allopurinol.
- Awareness of allopurinol-induced hepatomegaly is crucial for timely diagnosis and management, especially in elderly populations.
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