Jove
Visualize
Contact Us

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Mutations01:39

Mutations

Overview
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Absorption of Radiation01:05

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Mouse Ear Model for Bystander Studies Induced by Microbeam Irradiation.

Radiation research·2015
Same author

ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs--threshold doses for tissue reactions in a radiation protection context.

Annals of the ICRP·2012
Same author

Significant reduction in dental cone beam computed tomography (CBCT) eye dose through the use of leaded glasses.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·2011
Same author

Radiation cataractogenesis: epidemiology and biology.

Radiation research·2010
Same author

Development and characterization of an H2O2-resistant immortal lens epithelial cell line.

Investigative ophthalmology & visual science·2000
Same author

The effect of catalase amplification on immortal lens epithelial cell lines.

Experimental eye research·1999
Same journal

Geiger-Müller counter tube survey metres with resolving times greater than approximately 2000 µs should not be used for contamination inspection at Operational Intervention Level 4.

Annals of the ICRP·2026
Same journal

A multidisciplinary challenge to assess the next-generation risks of low-dose-rate long-term gamma-ray exposure by whole-genome sequencing in the mouse model.

Annals of the ICRP·2026
Same journal

Rethinking tissue reactions to radiation exposure: The tissue-sparing effect as a threshold for radiation-induced male infertility.

Annals of the ICRP·2026
Same journal

Do not waste time and money for AOP: Admitting LNT as a scientific fact is the highest priority for revised general recommendation.

Annals of the ICRP·2026
Same journal

Haematopoietic stem cells in an organ-on-a-chip system for longterm ionising radiation studies.

Annals of the ICRP·2026
Same journal

Data that revolutionise the fundamentals of radiation protection over 100 years and WAM model.

Annals of the ICRP·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 17, 2026

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

Radiation cataract.

N J Kleiman1

  • 1Eye Radiation and Environmental Research Laboratory, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. njk3@columbia.edu

Annals of the ICRP
|October 24, 2012
PubMed
Summary
This summary is machine-generated.

Recent studies indicate radiation cataract can occur at lower doses than previously assumed. New guidelines propose lowering occupational exposure limits to protect against radiation-induced lens opacification.

More Related Videos

Modeling Cataract Surgery in Mice
05:19

Modeling Cataract Surgery in Mice

Published on: December 1, 2023

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
04:59

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Related Experiment Videos

Last Updated: May 17, 2026

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

Modeling Cataract Surgery in Mice
05:19

Modeling Cataract Surgery in Mice

Published on: December 1, 2023

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries
04:59

Rotating the Intraocular Lens to Prevent Posterior Capsular Opacification in Cataract Surgeries

Published on: July 7, 2023

Area of Science:

  • Ophthalmology
  • Radiation Biology
  • Occupational Health

Background:

  • Historically, radiation cataract was considered a deterministic event with high dose thresholds (>2 Gy).
  • Previous studies had limitations including short follow-up periods and insufficient data at lower doses.
  • Newer evidence suggests a dose-response relationship for lens opacification at significantly lower radiation levels.

Purpose of the Study:

  • To re-evaluate current ocular exposure guidelines for radiation.
  • To propose revised occupational lens exposure limits based on emerging scientific findings.
  • To investigate the cellular and molecular mechanisms of radiation-induced lens opacification.

Main Methods:

  • Review of recent epidemiological studies on diverse populations exposed to various radiation doses.
  • Analysis of experimental animal studies investigating radiation effects on the lens.
  • Evaluation of cellular and molecular mechanisms, including genotoxicity.

Main Results:

  • New findings strongly suggest dose-related lens opacification occurs at significantly lower radiation doses than previously believed.
  • A re-evaluation led to proposed revisions: a presumptive radiation cataract threshold of 0.5 Gy/year and an occupational lens exposure limit of 20 mSv/year.
  • Experimental studies support these findings and suggest genotoxicity plays a role.

Conclusions:

  • The threshold for radiation-induced lens opacification is likely much lower than previously established.
  • Revised occupational exposure guidelines are recommended to mitigate risks.
  • These findings have significant implications for occupational eye protection, particularly in fields like interventional medicine.