Related Experiment Video
Updated: May 17, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
[Primary bone lymphoma with multicentric involvement]
Marcelo Graziadio1, Natalia Medina, Marcelo Amato
1Servicio de Clínica Médica, Hospital Ramos Mejía, Buenos Aires, Argentina. marcelograziadio@hotmail.com
Medicina
|October 24, 2012
Summary
Primary bone lymphoma, a rare condition, can present aggressively. This case highlights rapid growth in cranial and sternal locations, successfully treated with R-CHOPP chemotherapy.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Primary bone lymphoma (PBL) is a rare extranodal non-Hodgkin lymphoma.
- PBL typically presents with distinct clinical behavior compared to lymphomas in other sites.
Observation:
- A case of rapidly progressing PBL involving cranial and sternal bone locations is presented.
- Following surgical excision of the initial cranial lesion, new lesions emerged rapidly in the skull and femur, with progression at the sternal site.
Findings:
- Histopathological analysis revealed diffuse large B-cell non-Hodgkin lymphoma.
- The patient received standard R-CHOPP (cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab) chemotherapy.
- All lesions showed a rapid reduction in size, with no evidence of disease progression after six cycles of treatment.
Implications:
- This case underscores the aggressive nature of certain primary bone lymphomas.
- R-CHOPP chemotherapy demonstrated significant efficacy in managing rapidly progressing PBL.
- Early diagnosis and prompt treatment are crucial for favorable outcomes in primary bone lymphoma.
Related Concept Videos
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:29Bone Disorders
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...