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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides (CHIPS)
Published on: June 20, 2014
Maleimide-functionalized photochromic spirodihydroindolizines
Tej B Shrestha1, Mausam Kalita, Megh Raj Pokhrel
1Department of Anatomy & Physiology, Kansas State University, Coles 130, Manhattan, Kansas 66506, United States. tbs3@vet.k-state.edu
Abstract:
Two photochromic spirodihydroindolizine/betaine systems for tethering to peptides and proteins via a maleimide function have been prepared. The absorption spectra of the betaines are in the red region of the visible spectrum and in the near-IR spectral domain, which are suitable energies of light for future in vivo applications. The half-times of cyclization have been determined for both DHI/betaine systems. The findings are consistent with a thermal barrier of varying size between the transoid and cisoid conformers of the betaines.
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