Interleukin 10 polymorphisms and cervical cancer risk: a meta-analysis
1Department of Gynecologic Oncology, Jiangsu Cancer Hospital and Research Institute, Nanjing Medical University, Nanjing, China.
Summary
Interleukin 10 (IL-10) gene polymorphisms were analyzed for cervical cancer risk. The IL-10-592C/A variant is a risk factor, particularly for Asians, while IL-10-1082G/A showed no overall association.
Area of Science:
- Genetics
- Oncology
- Immunology
Background:
- Interleukin 10 (IL-10) is an immune-regulatory cytokine with a role in cancer development.
- Polymorphisms in the IL-10 gene, specifically at the -1082G/A and -592C/A loci, have been investigated for their potential association with cervical cancer risk.
- Existing studies present conflicting results, necessitating a comprehensive meta-analysis to clarify the relationship.
Purpose of the Study:
- To conduct a meta-analysis to determine the association between IL-10 gene polymorphisms (-1082G/A and -592C/A) and the risk of developing cervical cancer.
- To provide a more precise estimation of the risk conferred by these IL-10 polymorphisms.
Main Methods:
- A meta-analysis was performed on eligible studies investigating IL-10 -1082G/A and -592C/A polymorphisms in relation to cervical cancer.
- Data from 8 studies (1498 cases, 1608 controls) for -1082G/A and 5 studies (2396 cases, 1388 controls) for -592C/A were pooled.
- Fixed-effects or random-effects models were used to derive pooled odds ratios (ORs), with subgroup analyses conducted by ethnicity and Hardy-Weinberg equilibrium.
Main Results:
- The IL-10-1082G/A polymorphism showed no significant association with overall cervical cancer risk.
- However, the IL-10-1082A allele was linked to decreased risk among white populations.
- The IL-10-592C/A polymorphism was significantly associated with an elevated risk of cervical cancer in the overall analysis (OR=1.16) and particularly among Asians (OR=1.23).
Conclusions:
- The IL-10-1082G/A polymorphism does not appear to influence overall cervical cancer risk.
- The IL-10-592C/A genetic polymorphism is identified as a risk factor for cervical cancer, with a notable increase in risk observed in Asian populations.
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