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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification
07:23

Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification

Published on: December 3, 2016

Pubertal disorders and bone maturation.

Liora Lazar1, Moshe Phillip

  • 1The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva 49202, Israel.

Endocrinology and Metabolism Clinics of North America
|October 27, 2012
PubMed
Summary
This summary is machine-generated.

Bone age (BA) assessment reveals an individual's maturity and growth potential, aiding in diagnosing puberty variations. This skeletal age estimation is crucial for evaluating early or delayed sexual maturation in children.

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Area of Science:

  • Pediatric endocrinology and skeletal development.
  • Radiographic assessment of growth and maturation.

Background:

  • Chronologic age is insufficient for accurately assessing an individual's progression toward full maturity.
  • Bone age (BA) provides a clearer indication of skeletal maturity and predicts future growth potential.
  • Accurate assessment of skeletal maturity is vital for diagnosing and managing various pediatric endocrine and growth disorders.

Purpose of the Study:

  • To highlight the importance of bone age (BA) estimation in pediatric assessment.
  • To demonstrate the utility of BA in diagnosing normal puberty and its variants.
  • To emphasize BA's role in evaluating children with early or delayed sexual maturation.

Main Methods:

  • Utilizes single or serial skeletal age estimations.
  • Employs radiographic assessment of bone maturation.
  • Integrates BA findings into the overall clinical evaluation of pediatric patients.

Main Results:

  • Bone age (BA) is a more precise indicator of skeletal maturity than chronologic age.
  • BA aids in confirming diagnoses of normal puberty and variants like constitutional delay, premature thelarche, and precocious adrenarche.
  • BA provides essential qualitative information that complements clinical findings for accurate diagnosis.

Conclusions:

  • Bone age (BA) assessment is indispensable for evaluating growth and pubertal development in children.
  • BA is critical for the clinical workup of pediatric patients with atypical sexual maturation.
  • While qualitative, BA is a vital component of diagnostic information in pediatric endocrinology.