Related Experiment Video
Updated: May 17, 2026
06:19
Label-Free Surface-Enhanced Raman Scattering Bioanalysis Based on Au@Carbon Dot Nanoprobes
Published on: June 9, 2023
Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering
Steven M Asiala1, Zachary D Schultz
1University of Notre Dame, Department of Chemistry and Biochemistry, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.
Chemical Communications (Cambridge, England)
|October 30, 2012
Abstract:
We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the millisecond time scale.
