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Renal-sparing regimens employing new agents
Richard Ruiz1, Goran B Klintmalm
1Annette C and Harold C Simmons Transplant Institute, Baylor University Medical Center, Dallas and Baylor All Saints Medical Center, Fort Worth, Texas 75246, USA.
Current Opinion in Organ Transplantation
|November 1, 2012
Summary
New immunosuppressive agents show promise for protecting kidney function after organ transplant. Research highlights belatacept, sotrastaurin, everolimus, and mycophenolate mofetil as potential renal-sparing options.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- Renal compromise is a significant challenge in organ transplantation.
- Minimizing damage to native kidneys and allografts is crucial.
- Immunosuppressive regimens are key to managing renal function post-transplant.
Purpose of the Study:
- To review recent studies on immunosuppressive agents for renal protection in transplant patients.
- To evaluate novel and existing therapies for preserving kidney function.
Main Methods:
- Review of recent clinical studies and investigations.
- Analysis of immunosuppressive agents including belatacept, sotrastaurin, everolimus, and mycophenolate mofetil.
- Comparison of agent efficacy and renal-sparing potential.
Main Results:
- Belatacept demonstrated sustained renal function benefit compared to cyclosporine.
- Sotrastaurin showed promise for graft function but lacked immunosuppressive potency.
- Everolimus, with reduced calcineurin inhibitors, is a promising renal-sparing option.
- Mycophenolate mofetil may offer advantages in monotherapy for long-term use.
Conclusions:
- Investigated therapies offer potential alternatives for immunosuppression.
- No current regimen significantly surpasses calcineurin inhibitors in overall efficacy.
- Continued research is needed to minimize chronic kidney disease in transplant recipients.
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