Diffuse uptake of osteotropic radionuclide in the breast secondary to superior vena caval obstruction

Osteotropic radionuclide uptake in breast tissue has been described in a variety of benign and malignant lesions. The authors present a case of diffuse unilateral breast uptake secondary to neoplastic obstruction of the right brachiocephalic vein and superior vena cava. Following radiotherapy, the vascular obstruction resolved and the breast uptake was no longer observed.