Related Experiment Video
Updated: May 17, 2026
08:58
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
Treatment of experimental ulcerative colitis
L B Lazebnik1, A E Lychkova, O V Knyazev
1Institute of Gastroenterology, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|November 1, 2012
Summary
Infliximab, an anti-cytokine drug, was studied for ulcerative colitis treatment. It prevented toxic dilation and maintained smooth muscle activity by preserving nerve cell function.
Area of Science:
- Gastroenterology
- Pharmacology
- Neuroscience
Background:
- Ulcerative colitis is a chronic inflammatory bowel disease.
- Anti-cytokine therapies offer potential treatment avenues.
Purpose of the Study:
- To investigate the therapeutic effects of infliximab on experimental ulcerative colitis.
- To elucidate the mechanisms underlying infliximab's action on gastrointestinal smooth muscles.
Main Methods:
- Ulcerative colitis was induced using picrylsulfonic acid injection in an animal model.
- The effects of infliximab on smooth muscle bioelectric activity and neuronal function were assessed.
Main Results:
- Infliximab administration prevented the development of toxic dilatation in the colon.
- The drug maintained the bioelectric activity of smooth muscles.
- Infliximab preserved the activity of intramural nervous system neurons.
Conclusions:
- Infliximab demonstrates protective effects against experimental ulcerative colitis.
- The drug's mechanism involves preserving intramural nervous system neuron activity, thereby maintaining smooth muscle function.
Related Concept Videos
01:29Drugs for Treatment of Ulcerative Colitis in IBD
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...