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Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
Published on: October 13, 2015
Subacute endocarditis caused by Yersinia enterocolitica: a case report
Alessandro Lupi1, Federica Poletti, Vincenzo Mondino
1Cardiology II, University Hospital Maggiore della Carità, Novara, Italy. lupialessandro1@tin.it
Scandinavian Journal of Infectious Diseases
|November 2, 2012
Summary
Yersinia enterocolitica rarely causes sepsis, but can infect heart valves, even in non-immunocompromised individuals. Prompt antibiotic treatment led to recovery in this unusual case of subacute endocarditis.
Area of Science:
- Infectious Diseases
- Cardiology
- Internal Medicine
Background:
- Yersinia enterocolitica is an uncommon pathogen, typically causing gastrointestinal illness.
- Septicemia due to Yersinia enterocolitica is rare, particularly in patients without significant immunocompromise.
- Endocardial involvement, presenting as infective endocarditis, is an even rarer manifestation.
Observation:
- A 73-year-old woman presented with prolonged fever, arthralgia, and weight loss.
- Blood and urine cultures identified Yersinia enterocolitica.
- Echocardiography revealed a vegetation on the aortic valve, suggesting endocarditis.
Findings:
- The patient, without apparent risk factors for endocarditis, was successfully treated with intravenous cefotaxime and amikacin, followed by ceftriaxone.
- Clinical symptoms and fever resolved within 3 days of initiating antibiotic therapy.
- The patient's prior chemotherapy for breast cancer was considered a potential predisposing factor.
Implications:
- This case highlights the potential for Yersinia enterocolitica to cause subacute endocarditis in atypical hosts.
- The subacute presentation may be influenced by partial immune recovery post-chemotherapy.
- Early diagnosis and appropriate antibiotic therapy are crucial for managing this rare but serious infection.
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