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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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Bilateral aggressive inverted papillomas: A changing scenario.

Naresh K Panda1, K Saravanan, R K Verma

  • 1Department of Otolaryngology, Head and Neck surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India 160 012.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|November 3, 2012
PubMed
Summary
This summary is machine-generated.

Aggressive inverted papillomas, often recurrent and bilateral, require tailored surgical management. Adjuvant radiotherapy can play a role in controlling these challenging sinonasal tumors.

Keywords:
Bilateral lateral rhinotomyBilateral papillomaIntracranial extension

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Area of Science:

  • Otolaryngology
  • Head and Neck Surgery
  • Oncology

Background:

  • Bilateral, recurrent inverted papillomas present a complex management challenge.
  • Previous surgical interventions may not prevent aggressive tumor behavior and recurrence.

Purpose of the Study:

  • To describe the management strategies for aggressive, bilateral, and recurrent inverted papillomas.
  • To evaluate the effectiveness of different surgical approaches and adjuvant radiotherapy.

Main Methods:

  • Retrospective case series of three patients with aggressive inverted papillomas.
  • Surgical excision via bilateral lateral rhinotomy, midfacial degloving, or craniofacial approaches.
  • Histopathological analysis to identify mitotic figures guiding treatment decisions.

Main Results:

  • One patient experienced recurrence after midfacial degloving, successfully treated with lateral rhinotomy.
  • Two patients received adjuvant radiotherapy due to histopathological findings.
  • All patients remained asymptomatic at a 6-month follow-up.

Conclusions:

  • Aggressive inverted papillomas can manifest with recurrence, bilateral involvement, or intracranial extension.
  • Bilateral lateral rhinotomy or craniofacial resection are effective surgical options.
  • Adjuvant radiotherapy is a valuable tool for managing recurrences.