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Related Experiment Videos

Alcohol for surgical scrubbing?

E L Larson1, A M Butz, D L Gullette

  • 1Johns Hopkins University School of Nursing, Baltimore, MD 21205.

Infection Control and Hospital Epidemiology
|March 1, 1990
PubMed
Summary
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70% ethyl alcohol with 0.5% chlorhexidine gluconate (ALC) proved effective in reducing hand flora during surgical scrubbing. ALC demonstrated significant microbial reduction compared to control, making it a viable alternative.

Area of Science:

  • Microbiology
  • Infectious Disease Control
  • Dermatology

Background:

  • Surgical site infections are a major concern in healthcare.
  • Effective surgical hand antisepsis is crucial for preventing pathogen transmission.
  • Evaluating new antiseptic formulations is essential for improving patient safety.

Purpose of the Study:

  • To compare the efficacy of four surgical scrub products against a nonantimicrobial soap control.
  • To assess the impact of different antiseptic agents on hand flora over five days.
  • To determine the duration of microbial reduction after surgical scrubbing and gloving.

Main Methods:

  • Sixty healthy volunteers participated in a five-day surgical scrub protocol.
  • Hand cultures were collected at baseline, post-scrub, and after four hours of gloving.

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  • Formulations tested included 70% ethyl alcohol with 0.5% chlorhexidine gluconate (ALC), triclosan, chlorhexidine gluconate (CHG), and povidone-iodine (PI).

    • Main Results:

    • ALC, CHG, and PI significantly reduced hand flora compared to the control after scrubbing.
    • ALC showed a nearly 3-log reduction in flora by day 5, superior to CHG, PI, triclosan, and control.
    • ALC, TRI, and CHG significantly reduced microbial counts after gloving, unlike PI.

    Conclusions:

    • 70% ethyl alcohol with 0.5% chlorhexidine gluconate (ALC) is an effective and acceptable surgical scrub alternative.
    • ALC provides superior and more sustained antimicrobial activity compared to other tested agents.
    • Further research may explore long-term effects and broader clinical applications of ALC.