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Updated: May 17, 2026
Preparation of Quality Inositol Pyrophosphates
Published on: September 3, 2011
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts
Rania M Deranieh1, Miriam L Greenberg, Pierre-B Le Calvez
1College of Liberal Arts and Sciences, Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.
Abstract:
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
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