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Updated: May 17, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Bortezomib-induced bronchiolitis obliterans organizing pneumonia
E Vandeix1, F Favard, N Pichon
1Medical-Surgical Intensive Care Unit, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France ; Department of Pulmonology, Dupuytren University Hospital, 2 Avenue Martin Luther King, 87000 Limoges, France.
Abstract:
Introduction. Bortezomib is a proteasome inhibitor indicated for the treatment of multiple myeloma patients. The most frequent side effects are gastrointestinal and neurological. Serious pulmonary complications have been described rarely. Observation. This case involves a 74-year-old man suffering from IgG Kappa myeloma treated with bortezomib, melphalan, and dexamethasone. After administering chemotherapy, the patient developed an acute respiratory distress syndrome (ARDS). A surgical pulmonary biopsy proved the existence of bronchiolitis obliterans organizing pneumonia (BOOP) lesions. Systemic corticotherapy led to a rapid improvement in the patient's condition. Conclusion. This is the first reported histologically confirmed case of bortezomid-induced BOOP. Faced with severe respiratory symptoms in the absence of other etiologies, complications due to bortezomid treatment should be evoked and corticotherapy considered.
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